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Maui Derm News: Delgocitinib Cream Bests Alitretinoin in Phase 3 CHE Trial

The Dermatology Digest

Delgocitinib cream 20mg/g bested oral alitretinoin for the treatment of chronic hand eczema, according to the Phase 3 DELTA FORCE trial. The topical pan-Janus kinase (JAK) inhibitor demonstrated superior treatment effects, quality of life improvements, and a more favorable safety profile compared to oral alitretinoin over 24 weeks.

Eczema 36
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MHRA Grants Marketing Authorization for LEO Pharma’s CHE Cream in Great Britain

The Dermatology Digest

The Medicines and Healthcare Products Regulatory Agency (MHRA) has granted marketing authorization in Great Britain for delgocitinib cream (Anzupgo, Leo Pharma) for the treatment of adult patients with moderate to severe chronic hand eczema (CHE), for whom topical corticosteroids are inadequate or inappropriate.

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Late-Breaking Data: Long-Term Safety and Efficacy of Delgocitinib Cream for Chronic Hand Eczema

Dermatology Times

Melinda Gooderham, MSc, MD, FRCPC, provided insights into the significance of the DELTA 3 extension data presented at AAD 2024.

Eczema 74
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Ruxolitinib Cream Shows Strong Efficacy in Max-Use Pediatric Trial

Dermatology Times

A study revealed ruxolitinib cream's rapid, lasting benefits in pediatric eczema without systemic safety concerns over a 52-week trial period.

Eczema 74
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AD Pipeline Watch: First Patient Enrolled in Phase 2 Study of Evommune’s IL-18 Blocker

The Dermatology Digest

The multi-center, randomized, double-blind, placebo-controlled, proof-of-concept trial is designed to evaluate the safety and efficacy of EVO301 in approximately 60 adult patients with moderate-to-severe AD. EASI, the Eczema Area and Severity Index score, isa tool used to measure the extent and severity of atopic dermatitis.

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If Fragrance In Skincare Scares You, Read This

Renee Rouleau

Take Vaseline, for instance—Vaseline is petroleum jelly, a petroleum-derived product, and it’s considered so safe that it’s even recommended by the National Eczema Foundation. The bottom line is that synthetic fragrances are extremely pure and predictable since they’re made in a lab, so their safety is well understood.

Skincare 195
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AD Pipeline Watch: Amgen, Kyowa Kirin’s Anti-OX40 Candidate Meets Endpoints in AD Trial

The Dermatology Digest

The IGNITE study was a 24-week, randomized, placebo-controlled, double-blind study to assess the efficacy, safety and tolerability of rocatinlimab monotherapy every four weeks in 769 adults with moderate to severe AD, including patients previously treated with a biologic or systemic Janus kinase (JAK) inhibitor medication. At week 24, 42.3%