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Head to Head Study: LEO Pharma’s Delgocitinib Cream Bests Alitretinoin for Severe Chronic Hand Eczema 

The Dermatology Digest

Delgocitinib cream demonstrated a superior reduction in Hand Eczema Severity Index (HECSI) score from baseline to Week 12 compared to alitretinoin capsules in people with severe chronic hand eczema, according to results from the DELTA FORCE Trial, which is the first head-to-head phase 3 trial comparing a systemic and topical treatment for CHE.

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Dermavant Submits Supplemental sNDA to FDA for VTAMA Cream for AD in Adults and Children 2 Years of Age and Older  

The Dermatology Digest

The prevalence of atopic dermatitis, an extremely burdensome skin condition, continues to grow, and there is an increasing need for new, long-term, treatment options, especially for children,” says Todd Zavodnick, Chief Executive Officer of Dermavant, in a news release.

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Dermavant’s Vtama Performs Well in Phase 3 AD Studies; New Data Paves Way for Upcoming sNDA Submission

The Dermatology Digest

of atopic dermatitis (AD) patients using Vtama (tapinarof) cream, 1% achieved Eczema Area and Severity Index (EASI )75 in an integrated analysis of all the ADORING Program studies, Dermavant reports. Storrs Medical Dermatology Professor and Director of CLEAR Eczema Center, at the Oregon Health & Science University, in a news release.

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AD Pipeline Watch: Aslan Reports “Spectacular Results” in Phase 2 Study of Eblasakimab That Included Some Dupilumab-experienced Patients

The Dermatology Digest

Adult atopic dermatitis (AD) patients previously treated with dupilumab (Dupixent, Regeneron and Sanofi) who received 400mg eblasakimab weekly achieved Eczema Area Severity Index (EASI) 90, and 66.7% Treatment was well-tolerated and no new safety signals were identified.

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AD Pipeline Watch: Inmagene’s Anti-OX40 Monoclonal Antibody Performs Well in Phase 2a AD Trial

The Dermatology Digest

The Phase 2a trial ( NCT05984784 ) evaluates the safety, pharmacokinetics, and efficacy of IMG-007 in adult patients with moderate-to-severe AD who had inadequate response to and/or intolerant of topical therapies. Key study endpoints include safety and percent change from baseline in eczema area and severity index (EASI) over time.

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TDD AD Pipeline Watch:  Aldeyra’s ADX?629 Performs Well in Phase 2 Study 

The Dermatology Digest

The primary endpoint of the clinical trial was safety and tolerability. Statistical significance was achieved for improvement in patient-reported eczema severity; the clinically relevant threshold of improvement by 4 or more points was met in six patients (75%). Brady, MD, PhD, President and Chief Executive Officer of Aldeyra.

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TDD Industry News and Views: Weekly Updates on Comings, Goings, and Other Happenings in Dermatology

The Dermatology Digest

Tim Raducha-Grace Named Chief Platform Officer at Zerigo Health Tim Raducha-Grace is the new Chief Platform Officer at Zerigo Health, a connected phototherapy platform that couples a handheld Narrow-band ultraviolet B (NB-UVB) light device with a smartphone app and team of care providers to allow patients to treat psoriasis and eczema at home.