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E.C. Approves Leo’s Delgocitinib Cream (Anzupgo) for CHE; FDA Accepts New Drug Application for Delgocitinib Cream in CHE

The Dermatology Digest

has given its official nod to delgocitinib (Anzupgo, Leo Pharma) cream for adults with moderate to severe chronic hand eczema (CHE). These trials evaluated the safety and efficacy of delgocitinib compared to cream vehicle. The European Commission (E.C.) In addition, the U.S. Both trials met their primary and all secondary endpoints.

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More Breaking News: U.S. FDA Approves Nemolizumab (Nemluvio, Galderma) for Patients with Moderate to Severe AD

The Dermatology Digest

This approval is based on positive results from the phase III ARCADIA clinical trial program which evaluated the efficacy and safety of nemolizumab in combination with background TCS, with or without TCI, versus placebo in combination with TCS, with or without TCI, in 1,728 patients aged 12 or older with moderate to severe atopic dermatitis.

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Head to Head Study: LEO Pharma’s Delgocitinib Cream Bests Alitretinoin for Severe Chronic Hand Eczema 

The Dermatology Digest

Delgocitinib cream demonstrated a superior reduction in Hand Eczema Severity Index (HECSI) score from baseline to Week 12 compared to alitretinoin capsules in people with severe chronic hand eczema, according to results from the DELTA FORCE Trial, which is the first head-to-head phase 3 trial comparing a systemic and topical treatment for CHE.

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Best Foods to Avoid for Eczema 2024

Aesthetics Advisor

Infants of mothers randomized to cut out eggs, milk, and fish were significantly less likely to have eczema even years later. Eczema, also known as atopic dermatitis, is a chronic inflammatory skin disease. You know the medical profession is desperate when they’re forced to go back to the basics and start applying leeches to people.

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Retinol Serum: Is It Safe for Kids and Teens?

First Derm

Social media significantly influences the popularity of retinol among young people, leading to increased experimentation without considering safety. There’s a crucial difference between cosmetic retinol use and medical treatment with retinoids ; the latter is for specific skin conditions under professional supervision.

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Breaking News from Maui Derm: Research Supports the Safety and Efficacy of Delgocitinib in CHE

The Dermatology Digest

Delgocitinib cream continues to perform well in chronic hand eczema (CHE), with limited systemic exposure, according to two studies presented at the 2024 Maui Dermatology conference. What’s more, delgocitinib cream 20 mg/g was well-tolerated over 16 weeks, and no safety concerns were identified. Study author Melinda J.

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FDA, EMA Accept Galderma’s BLA for Nemolizumab for PN and AD

The Dermatology Digest

“We are thankful to the patients and medical experts whose insights informed our clinical trials, which assessed nemolizumab’s ability to reduce the symptoms of itch and skin lesions. Nemolizumab was generally well tolerated and its safety profile was similar to placebo across the OLYMPIA and ARCADIA clinical trial programs.