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Important Updates on the Efficacy and Safety of JAK Inhibitors in Dermatology

The Dermatology Digest

Raj Chovatiya, MD, PhD, Founder and Director of the Center for Medical Dermatology and Immunology Research in Chicago, IL, reviews the latest efficacy and safety data on oral and topical Janus kinase (JAK) inhibitors used in dermatology. He spoke on this topic at the 2024 Revolutionizing Atopic Dermatitis (RAD) Conference.

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Analyzing the Safety of JAK Inhibitors in Atopic Dermatitis Treatment

Dermatology Times

Ruth Ann Vleugels, MD, and Christopher Bunick, MD, agreed that the long-term safety data for JAK inhibitors makes them preferable to systemic steroids.

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Understanding Drug Interactions in Systemic Treatment: Impact on Atopic Dermatitis Symptoms

Dermatology Times

Dr Alexandra Golant discusses managing multiple conditions in a 17-year-old African American waitress, highlighting the complexities of treating moderate-to-severe atopic dermatitis alongside severe acne and oral contraceptives. She also addresses potential drug interactions, focusing on the safety of dupilumab in systemic treatment.

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Long-Term Safety of Dupilumab in Adults with Moderate to Severe Atopic Dermatitis

Dermatology Times

The results from this 5-year open-label extension trial affirm the safety of dupilumab in adults with moderate to severe AD.

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FDA Updates Dupilumab Label With Hand, Foot Atopic Dermatitis Involvement

Dermatology Times

The FDA has added efficacy and safety data for patients ages 12 years and older with uncontrolled moderate-to-severe atopic dermatitis with hand and/or foot involvement.

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New Phase 3 Data on Long-Term Efficacy of Upadacitinib in Atopic Dermatitis Presented at EADV

Dermatology Times

The data presents compelling evidence for the sustained efficacy and safety of the oral JAK1 inhibitor in the treatment of moderate to severe atopic dermatitis over an extended 140-week period.

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Utilizing Safety Data When Prescribing Ruxolitinib Cream for Atopic Dermatitis

Dermatology Times

The panelist discusses how safety data from clinical trials and real-world evidence should guide physicians in prescribing ruxolitinib cream, including patient monitoring protocols and managing potential adverse effects in atopic dermatitis treatment.

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