The Dermatology Digest

APRIL 30, 2024

Eli Lilly has resubmitted its Biologics License Application (BLA) for Lebrikizumab for the treatment of moderate to severe atopic dermatitis (AD), with regulatory action anticipated in the second half of 2024. There were no concerns with lebrikizumab’s clinical data package, safety, or label.

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The Dermatology Digest

JANUARY 14, 2024

The overwhelming majority of people with atopic dermatitis (AD) treated with investigational roflumilast cream 0.15% (Zoryve, Arcutis) showed a measurable improvement in Eczema Area and Severity Index (EASI) in 4 weeks, according to new pooled analyses from two Phase 3 studies. Fully 91.5%

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The Dermatology Digest

MARCH 10, 2024

More than two-thirds of people with atopic dermatitis (AD) and darker skin tones treated with lebrikizumab showed improvements in skin clearance and itch relief, according to late-breaking results from a Phase 3 study are being presented at the 2024 American Academy of Dermatology (AAD) Annual Meeting in San Diego.

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The Dermatology Digest

AUGUST 13, 2024

FDA The approval is based on positive results from the phase III OLYMPIA clinical trials – the largest clinical trial program conducted in this condition to date – in which nemolizumab demonstrated significant and clinically meaningful improvements in itch and skin nodules at Week 16, with rapid reductions in itch observed as early as Week 4.

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The Dermatology Digest

JANUARY 23, 2024

Nemolizumab improves skin lesions, itch, and sleep disturbance in patients with moderate-to-severe atopic dermatitis (AD), according to results from two phase 3 studies. Galderma’s nemolizumab is a first-in-class interleukin-31 receptor alpha antagonist that is under investigation for atopic dermatitis.

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The Dermatology Digest

JULY 10, 2024

for use in moderate to severe atopic dermatitis (AD) in the NHS England. The letter stated no concerns about the clinical data package, safety, or label for lebrikizumab. The National Institute for Health and Care Excellence (NICE) now recommends lebrikizumab (Ebglyss, Almirall S.A.)

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The Dermatology Digest

JUNE 14, 2024

Food and Drug Administration (FDA) has cleared InnoCare Pharma’s investigational new drug application (IND) for ICP-332, a tyrosine kinase 2 (TYK2) inhibitor that’s being studied in moderate to severe atopic dermatitis (AD). Currently, no TYK2 inhibitors have obtained marketing approval for the treatment of AD.

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The Dermatology Digest

JULY 16, 2024

is starting its global Phase 3 program, consisting of two Phase 3 trials (EMBARQ-CSU1 and EMBARQ-CSU2) designed to establish the efficacy and safety of barzolvolimab in adult patients with chronic spontaneous urticaria (CSU) who remain symptomatic despite H1 antihistamine treatment. Celldex Therapeutics, Inc.

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The Dermatology Digest

DECEMBER 15, 2023

Food and Drug Administration (FDA) has given its nod to topical roflumilast foam (Zoryve, Arcutis) for seborrheic dermatitis. The PDE4 inhibitor is the first topical treatment for seborrheic dermatitis with a new mechanism of action in more than 20 years. in seborrheic dermatitis.

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The Dermatology Digest

FEBRUARY 16, 2024

The safety profile of dupilumab in CSU was generally consistent with the known safety of Dupixent in its approved dermatological indications. In addition to CSU, dupilumab is approved in Japan in certain patients with atopic dermatitis, asthma, chronic rhinosinusitis with nasal polyposis (CRSwNP), and prurigo nodularis.

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The Dermatology Digest

FEBRUARY 8, 2024

It has great efficacy and safety and is oral… [This means] no shot and no risk of anaphylaxis.” Upadacitinib’s (Rinvoq, AbbVie) 5-yr safety data show that it is REALLY SAFE and effective in AD, and abrocitinib (Cibinqo, Pfizer) is safe as well.” Taking Seb Derm Seriously The U.S. The data on roflumilast foam are incredible,” he says.

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The Dermatology Digest

DECEMBER 15, 2023

Food and Drug Administration (FDA) has expanded the approval of tralokinumab-ldrm (Adbry, LEO Pharma Inc) to include kids aged 12-17 years with moderate-to-severe atopic dermatitis (AD) whose disease is not adequately controlled with topical prescription therapies or when those therapies are not advisable.

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The Dermatology Digest

DECEMBER 15, 2023

Food and Drug Administration (FDA) has expanded the approval of tralokinumab-ldrm (Adbry, LEO Pharma Inc) to include kids aged 12-17 years with moderate-to-severe atopic dermatitis (AD) whose disease is not adequately controlled with topical prescription therapies or when those therapies are not advisable.

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The Dermatology Digest

MARCH 11, 2024

In addition, results from the phase III ARCADIA clinical trials in atopic dermatitis (AD) found that nemolizumab-treated patients who responded at 16 weeks maintained skin and itch responses through to week 48, even when dosing was reduced from every four to every eight weeks. No new safety signals were observed in this trial.

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The Dermatology Digest

MAY 16, 2024

This grant will fund a collaborative effort to investigate the safety, tolerability, efficacy, and durability of response of subcutaneous administration of dupilumab in pediatric patients with extensive alopecia areata, defined as affecting at least 30% of the scalp.

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The Dermatology Digest

JULY 25, 2024

Galderma’s IL- 31 blocker nemolizumab performed well in the phase III ARCADIA 1 and 2 atopic dermatitis (AD) trials. The safety profile was consistent between nemolizumab and placebo groups; most treatment-emergent adverse events were non-serious, and of mild-to-moderate severity.

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The Dermatology Digest

DECEMBER 15, 2023

Food and Drug Administration (FDA) has expanded the approval of tralokinumab-ldrm (Adbry, LEO Pharma Inc) to include kids aged 12-17 years with moderate-to-severe atopic dermatitis (AD) whose disease is not adequately controlled with topical prescription therapies or when those therapies are not advisable.

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The Dermatology Digest

MARCH 11, 2024

Sanofi’s investigational OX40-ligand blocker amlitelimab produces sustained improvement in the signs and symptoms of atopic dermatitis (AD) in adults who previously responded and continued treatment and sustained off-drug improvements in those who stopped treatment.

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The Dermatology Digest

DECEMBER 18, 2023

New practice parameters from the Joint Task Force for Practice Parameter) recommend the use of topical corticosteroids or topical calcineurin inhibitors in patients with uncontrolled atopic dermatitis (AD) despite moisturizer use. Suggest the usage of crisaborole 2% ointment for mild to moderate atopic dermatitis. in a news release. “It

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First Derm

FEBRUARY 21, 2024

Social media significantly influences the popularity of retinol among young people, leading to increased experimentation without considering safety. However, there are concerns about the safety of using retinol on younger skin due to the physiological differences between children’s and adults’ skin.

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The Dermatology Digest

DECEMBER 20, 2023

Mr. Raducha-Grace recently served as Head of Clinical Partnerships at Harbor Health. The company is also conducting a 250-patient phase 2b trial of its topical JAK 1/3 inhibitor, called ATI-1777 in atopic dermatitis. Secondary measures of efficacy, as well as safety and pharmacokinetics, will also be assessed. Billingsley, MD.,

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Aesthetics Advisor

MARCH 10, 2024

Randomized, double-blind, controlled trials suggest that excluding certain foods, such as eggs and chicken, can significantly improve atopic dermatitis. Eczema, also known as atopic dermatitis, is a chronic inflammatory skin disease. Previously, I talked about the safety and efficacy of other, more natural treatments.

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The Dermatology Digest

JULY 21, 2023

Pandya, MD, Director, Pigmentary Disorders Clinic, Palo Alto Foundation Medical Group, Sunnyvale, California; and Adjunct Professor of Dermatology, University of Texas Southwestern Medical Center, Dallas, Texas “This is the most exciting time of my career when it comes to treatment of vitiligo. N Engl J Med. 2022;387(16):1445-1455.

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Aesthetics Advisor

AUGUST 6, 2023

Spreading throughout the American South, pellagra patients suffered severe symptoms known as the "4 D's": dermatitis, diarrhea, dementia, and death. Nicotinamide riboside's side effects NR is uniquely safe— it's been evaluated in 13 published human trials without any severe attributable side effects reported in clinical trials.

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The Dermatology Digest

MARCH 7, 2024

Alphyn’s zabalafin hydrogel (AB-101a) performed well in patients with atopic dermatitis (AD), including disease commonly associated with Staphylococcus aureus and methicillin-resistant Staph , according to new Phase 2a data.

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The Dermatology Digest

DECEMBER 19, 2023

Aldeyra Therapeutics’ investigational RASP modulator ADX-629 performed well in a Phase 2 clinical trial of patients with atopic dermatitis (AD), according to topline results. The open-label, single-center Phase 2 clinical trial of ADX-629 included eight mild-to-moderate AD patients.

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First Derm

DECEMBER 26, 2023

Dandruff (Seborrheic Dermatitis) Dandruff, medically known as seborrheic dermatitis , is a common scalp condition marked by excessive shedding of skin cells. Skin Conditions (Eczema, Psoriasis, Contact Dermatitis) as Causes of Dry, Itchy Scalp Various skin conditions can lead to a dry, itchy scalp: a.

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The Dermatology Digest

JANUARY 20, 2024

The study is designed to assess the safety, tolerability, and pharmacokinetics, of orally administered EVO756. Evommune’s pre-clinical data demonstrates that by blocking activation of MRGPRX2 and degranulation of mast cells, EVO756 has the potential to be a first-in-class oral treatment for a variety of mast cell-mediated diseases.

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The Dermatology Digest

MAY 6, 2024

The Phase 2a trial ( NCT05984784 ) evaluates the safety, pharmacokinetics, and efficacy of IMG-007 in adult patients with moderate-to-severe AD who had inadequate response to and/or intolerant of topical therapies. Key study endpoints include safety and percent change from baseline in eczema area and severity index (EASI) over time.

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The Dermatology Digest

JANUARY 20, 2024

The study is designed to assess the safety, tolerability, and pharmacokinetics, of orally administered EVO756. Evommune’s pre-clinical data demonstrates that by blocking activation of MRGPRX2 and degranulation of mast cells, EVO756 has the potential to be a first-in-class oral treatment for a variety of mast cell-mediated diseases.

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The Dermatology Digest

MARCH 5, 2024

APG777 is the first clinical-stage product candidate from the company’s strategic collaboration with Paragon Therapeutics, Inc. Based on these data, the company plans to initiate a randomized, placebo-controlled, Phase 2 clinical trial in patients with moderate-to-severe AD in the first half of 2024 ahead of schedule.

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Aesthetics Advisor

JUNE 16, 2024

A new review of studies published in the Journal of Clinical Medicine looked at whether nanofat injections are capable of improving skin tone and texture, and referenced one case where 5 ccs of nanofat visibly reduced the appearance of a patient’s fine lines and wrinkles a year after treatment. freeze) them.

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First Derm

FEBRUARY 7, 2024

Transmission Cycle : The disease is contracted through skin contact with contaminated freshwater, where parasitic worms from infected snails penetrate human skin, underscoring the importance of water safety. Clinical Spectrum of Schistosomiasis: An Update. Journal of Clinical Medicine. Schistosomiasis. Published February 2023.

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The Dermatology Digest

MARCH 11, 2022

And data from the 40-week, long-term extension study showed an impressive remittive effect and continued safety. Other than folliculitis, contact dermatitis was the only dermatologic adverse event that occurred at an overall rate >5%, and it was associated with study discontinuation rates of 1.5% and Canada. and 0.9%, respectively.”

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The Dermatology Digest

JANUARY 8, 2024

Based on these data, AbbVie will advance its clinical program of lutikizumab in HS to Phase 3. Kimball, MD, MPH, a professor of Dermatology at Harvard Medical School and the President and CEO of Harvard Medical Faculty Physicians at Beth Israel Deaconess Medical Center in Boston, in a news release. in the placebo group.

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The Beauty Brains

OCTOBER 17, 2016

According to Fisher’s Contact Dermatitis, acne can result from topical application of cosmetic products via two mechanisms. Their website includes links to clinical studies in which their product(s) were tested (single blind, half face test) against nothing. That’s a great question but patch testing for acne does NOT work.

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